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Nucleosides

Synthetic Nucleosides and protected nucleosides by Chemo-Enzymatic Hybrid Process

The company has developed a two-step chemical reaction process for manufacturing nucleosides and their analogs. Four kinds of high quality deoxynucleosides are available and feature:

Reliable traceability
  Clear impurity profile
  No animal ingredient

Chemo-enzymatic Hybrid Process

  1. The production of sugar phosphates stereoselectively and;
  2. The enzymatic coupling process of sugar phosphates with bases in a regio- and stereo-selective manner (see below).

     

 

Deoxy-Nucleosides

2'-Deoxy-D-adenosine monohydrate CAS 16373-93-6
2'-Deoxy-D-guanosine monohydrate CAS 961-07-9
2'-Deoxy-D-cytidine hydrochloride CAS 3992-42-5
D-Thymidine CAS 50-89-5

 

 

Protected Nucleosides

High purity 5'-DMT-protected derivatives for Amidite Nucleosides

The company uses a sophisticated chemical process using its synthetic deoxynucleosides to produce high quality protected nucleosides.

 

Protected Deoxy-Nucleosides

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine CAS 64325-78-6
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine CAS 68892-41-1
N4-Benzoyl -5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine CAS 67219-55-0
5'-O-(4,4'-Dimethoxytrityl)thymidine CAS 40615-39-2

 

 

Unnatural Nucleosides

(Application of the Chemo-Enzymatic Hybrid Process)

Mitsui Chemicals' enzymatic coupling process produces unnatural nucleosides stereo-selectively from dR-P and unnatural bases.

   

Contact us to learn more about our line of synthetic nucleosides and its applications.

Mitsui Chemicals Group